abstract::Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear. We used polymer simulations to model how physical parameters of chromatin affect its interaction with the lamina. Impact of ...
journal_title:Nucleus (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19491034.2020.1868105
更新日期:2021-12-01 00:00:00
abstract::The use of plants as a source of sedative or treatment for cancer is reasonably widespread worldwide. Annona muricata Linn exhibits a vast array of medicinal and ethno-pharmaceutical benefits, attributed by different plant parts. The activity of this plant is regarded to the bio-production of secondary metabolites lik...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2020.1846862
更新日期:2021-12-01 00:00:00
abstract::Ion channels play pivotal role in the physiological and pathological function of immune cells. As immune cells represent a functionally diverse population, subtype-specific functional studies, such as single-cell electrophysiology require proper subset identification and separation. Magnetic-activated cell sorting (MA...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2020.1859753
更新日期:2021-12-01 00:00:00
abstract::Ion channels underlie all forms for electrical signaling including the transmission of information about harmful events. Voltage-gated calcium ion channels have dual function, they support electrical signaling as well as intracellular calcium signaling through excitation-dependent calcium entry across the plasma membr...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2020.1860383
更新日期:2021-12-01 00:00:00
abstract::Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellula...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2020.1852831
更新日期:2021-12-01 00:00:00
abstract::The multiplication of social networking sites has led to increased frequency of use among young adults. While the association with mental wellbeing is still controversial, high levels of social media use were correlated with problematic behaviours, low self-esteem and depressive symptoms. 'Social Media Detoxification'...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2020.1846861
更新日期:2021-12-01 00:00:00
abstract::Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates silence of the inactive X. Previous studies of autosomal duplicatio...
journal_title:Nucleus (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19491034.2020.1850981
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To illustrate the effect of corticosteroids and heparin, respectively, on coronavirus disease 2019 (COVID-19) patients' CD8+ T cells and D-dimer. METHODS:In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were ...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1851394
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study was designed to uncover the mechanism of miR-34b-5p-mediated aquaporin-2 (AQP2) in sepsis-induced injury using human renal tubular epithelial cells (HK-2). METHODS:Serum levels of miR-34b-5p, TNF-α, IL-1β, IL-6, serum creatinine (SCr), and blood urea nitrogen (BUN) in septic patients with acute ki...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1871922
更新日期:2021-12-01 00:00:00
abstract::The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19) infection remains unclear. The impact of direct virus injury complicated by dysregulated hyperimmune response with overwhelming release of various cytokines in COVID-19 i...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1876730
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:As kidney disease progresses, patients often experience a variety of symptoms. There are very few studies reporting spectrum of predialysis patients' symptoms in peritoneal dialysis (PD) patients. Furthermore, the clinical significance of predialysis patients' symptoms for PD patients' progn...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1871920
更新日期:2021-12-01 00:00:00
abstract::We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1879316
更新日期:2021-12-01 00:00:00
abstract::Tinea is a common superficial infection caused by keratinophylic fungi called dermatophytes. The objective of the current investigation was to develop and optimize a self-nanoemulsion drug delivery system (SENDDs) using clove oil loaded with naftifine (NF). Clove oil possesses good anti-inflammatory and antifungal pro...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1879314
更新日期:2021-12-01 00:00:00
abstract::Vip3Aa is an insecticidal protein that can effectively control certain lepidopteran pests and has been used widely in biological control. However, the mechanism of action of Vip3Aa is unclear. In the present study, we showed that Vip3Aa could cause autophagy in Sf9 cells, which was confirmed by the increased numbers o...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1878747
更新日期:2021-12-01 00:00:00
abstract::Objectives: The 8p11 myeloproliferative syndrome (EMS) is an extremely rare, generally aggressive haematologic malignancies. This study provided the clinical outcomes and therapeutic strategies for EMS patients confirmed with CEP110-FGFR1 fusion. Methods: We report here a case of translocation (8;9) (p12;q33)/CEP110-F...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1854493
更新日期:2021-12-01 00:00:00
abstract::Bovine respiratory syncytial virus (BRSV) is a clinically important causative agent of acute respiratory diseases in postweaning calves and feedlot cattle and causes numerous economic losses to the cattle industry. In June 2018, an outbreak of an acute respiratory disease occurred among 4- to 10-month-old calves on th...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1872178
更新日期:2021-12-01 00:00:00
abstract::The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their reactivation ability was evaluated in vitro on human recombinant...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1869954
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Changes in fecal microbiota affect the incidence and extent of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Most patients with hematological malignancies receive antibiotics for the treatment of febrile neutropenia prior to allogeneic HSCT, and pre-transpl...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1872957
更新日期:2021-12-01 00:00:00
abstract::St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in t...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1869392
更新日期:2021-12-01 00:00:00
abstract::SARS-CoV-2 has spread rapidly, causing deaths worldwide. In this study, we evaluated the performance of the BD MAX Open System module for identifying viral pathogens, including SARS-CoV-2, in nasopharyngeal specimens from individuals with symptoms of upper respiratory tract infection. We developed and validated a rapi...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1873073
更新日期:2021-12-01 00:00:00
abstract::Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a-m and 9a-c) as promising anti-tubercular and antibacterial agents. The anti-tubercular activity of the target hybrids was evaluated against...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1868450
更新日期:2021-12-01 00:00:00
abstract::Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part in maintaining the co...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2020.1870060
更新日期:2021-12-01 00:00:00
abstract::Burkholderia territorii, a Gram-negative bacterium, encodes for the ι-class carbonic anhydrase (CA, EC 4.2.1.1) BteCAι, which was recently characterised. It acts as a good catalyst for the hydration of CO2 to bicarbonate and protons, with a kcat value of 3.0 × 105 s-1 and kcat/KM value of 3.9 × 107 M-1 s-1. No inhibit...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1867122
更新日期:2021-12-01 00:00:00
abstract::Most of the current approaches to influenza vaccine design focus on antibodies against influenza (HA). However, these influenza vaccines typically provide strain-specific protection against mostly homologous subtypes. There is an urgent need to develop a universal vaccine that confers cross-protection against influenz...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1857162
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:To evaluate any association between pre-transfusion hemoglobin (Hb) levels and thalassemia complications and to identify the Hb cutoff values to predict thalassemia complications. METHODS:We performed a cross-sectional study in thalassemia patients who attended the Adult Hematology Clinic of the tertiary ca...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1856513
更新日期:2021-12-01 00:00:00
abstract::Whereas the O104:H4 enterohemorrhagic Escherichia coli (EHEC) outbreak strain from 2011 expresses aggregative adherence fimbriae of subtype I (AAF/I), its close relative, the O104:H4 enteroaggregative Escherichia coli (EAEC) strain 55989, encodes AAF of subtype III. Tight adherence mediated by AAF/I in combination wit...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1868841
更新日期:2021-12-01 00:00:00
abstract::Co-occurrence of hypervirulence and KPC-2 carbapenem resistant phenotypes in a highly-transmissible ST11 clone ofKlebsiella pneumoniae has elicited deep concerns from public health stand point. To address this puzzle, we conducted a large-scale epidemiological, clinical and genomic study of K. pneumonia ST11 clones wi...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1867468
更新日期:2021-12-01 00:00:00
abstract::In this study, contrary to untreated poplar fiber, processing of alkali-treated poplar fiber was optimized for the enzymatic saccharification. Considering reducing sugar content as the evaluation index, pH, temperature, time, amount of enzyme, and rotational speed of shaker were standardized to optimize the sugar prod...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1857576
更新日期:2021-12-01 00:00:00
abstract::Recurrent aphthous ulcer (RAU) is a well-known painful, inflammatory disease with uncertain etiology for which local symptomatic therapy is only available. The aim of this study was to formulate and characterize muco-adhesive sponges containing a mixture of tenoxicam and miconazole nitrate to manage pain, inflammation...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1858999
更新日期:2021-12-01 00:00:00
abstract::In this investigation, we focused on ceramide IIIB, a skin component whose depletion tends to augment multiple skin disorders and fungal infections. Ceramide IIIB was included into PEGylated surfactant-based vesicular phospholipid system to formulate 'PEGylated cerosomes' (PCs) loaded with fenticonazole nitrate (FTN)....
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1859000
更新日期:2021-12-01 00:00:00
abstract::Bovine viral diarrhea virus (BVDV) is the causative agent of bovine viral diarrhea-mucosal disease, which significantly affects the production performance of cattle, causing serious economic losses to the cattle industries worldwide. Up to now, some mechanisms involved in host-BVDV interaction are still not fully unde...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1857572
更新日期:2021-12-01 00:00:00
abstract::In a group of 208 patients with chronic ischaemic heart disease, the variation of A2-associated-LDL phosphatase (Lp-PLA2) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA2 can be accepted as a biomarker with diag...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1839447
更新日期:2021-12-01 00:00:00
abstract::Design and fabrication of structurally optimized three-dimensional porous materials are highly desirable for engineering applications. Herein, through a facile bidirectional freezing technique, we prepared superelastic biomass sponges in air and underwater, which possess biomimetic porous sandwich-like architectures w...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118527
更新日期:2021-11-15 00:00:00
abstract::Construction of monolithic cryogels that can efficiently adsorb proteins is of great significance in biotechnological and pharmaceutical industries. Herein, a novel approach is presented to fabricate microfibrillated cellulose (MFC)/sodium alginate (SA) cryogels by using freezing-induced oxa-Michael reaction at -12 °C...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118498
更新日期:2021-11-15 00:00:00
abstract::The molecular weight (Mw) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and ac...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118461
更新日期:2021-11-15 00:00:00
abstract::Cutaneous wounds accompanied by massive bleeding, bacterial infections might be lethal and cause fundamental therapeutic impediments in clinical fields. As part of the push for a solution, biomaterial having hemostatic-antibacterial features is highly desirable. Inspired by this concept, freeze dried sponges were deve...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118482
更新日期:2021-11-15 00:00:00
abstract::Chitosan is a biopolymer that is natural, biodegradable, and relatively low price. Chitosan has been attracting interest as a matrix of nanocomposites due to new properties for various applications. This study presents a comprehensive overview of common and recent advances using chitosan as a nanocomposite matrix. The...
journal_title:Carbohydrate polymerspub_type: 杂志文章,评审
doi:10.1016/j.carbpol.2021.118472
更新日期:2021-11-15 00:00:00
abstract::Cellular viscosity is a prominent micro-environmental parameter and peroxynitrite is an essential reactive oxygen special, both of which are involved in various pathological and physiological processes. When the intracellular viscosity is abnormal or the ONOO- concentration is irregular, the normal function of cells w...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119990
更新日期:2021-11-05 00:00:00
abstract::Cryptococcus neoformans (C. neoformans) is a causative agent for acute pulmonary infection, which can further develop to lethal meningoencephalitis if untreated. The meningoencephalitis infection can be prevented, if timely treatment on pulmonary cryptococcal infection can be implemented based on its early diagnosis a...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119978
更新日期:2021-11-05 00:00:00
abstract::β-resorcylic acid (BR) is a phytochemical which is widely used in the food industry as a flavouring agent and preservative. It has also been found to exhibit antibacterial action against several types of food-borne bacteria. DNA is the main molecular target for many small molecules of therapeutic importance. Hence, th...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119952
更新日期:2021-11-05 00:00:00